A case of bleach addiction associated with severe obsessive-compulsive disorder.

Obsessive-compulsive disorders (OCDs) and substance use disorders (SUDs) are listed in two separate sections in psychiatric classifications. However, they share many clinical, physiological, and epidemiological aspects. SUDs affect more than one-quarter of individuals who seek treatment for OCD, and the lifetime comorbidity rate between OCD and SUDs reaches 27%. Furthermore, the co-occurrence of SUDs and OCD was shown to be higher than that of SUDs and other psychiatric disorders. By comparing brain activity during reward anticipation and receipt tasks between OCD patients and healthy control subjects, researchers found that OCD patients may be less able to make beneficial choices because of altered nucleus accumbens activation when anticipating rewards. This finding supports the conceptualization of OCD as a disorder of reward processing and behavioral addiction. We report a case study of a patient with OCD who has progressively developed a form of addiction to bleach use. To the best of our knowledge, bleach has not yet been described as an abused substance in OCD in the literature. The patient is a 50-year-old female with severe, treatment-resistant OCD and no lifetime history of SUDs. OCD onset was at the age of 23, following a traumatic rape. Her main obsessions were intrusive thoughts of dirtiness and contamination, and her compulsions were excessive washing and/or cleaning. She showered several times per day using a diluted solution of bleach in water; this routine took up to 8 hours daily. Furthermore, the frequency of her compulsions as well as the concentration of the bleach solution she used were exacerbated by her anxiety levels. Despite several dermatological lesions due to bleach use, efforts to stop these behaviors have been unsuccessful. In 4 years, she has had five overdose-like incidents which required immediate medical attention due to excessive inhalation of bleach fumes. In addition to these symptoms, which are very similar to diagnostic criteria for addiction, the patient described a bleach craving independently of her obsessive thoughts and compulsion toward dirtiness: she felt an urge to buy and use the product when it was available and developed a form of withdrawal symptoms when it was not. We tried to qualify and quantify this form of ‘‘bleach addiction’’ using the classical diagnostic criteria (DSM-5 Other SUD) and addiction scales with two independent assessments by trained psychiatrists (AP and RD). Results are presented in Table 1, as are OCD and general psychopathology scale scores. These results show that diagnostic criteria for SUD are met, with elevated scores on all severity scales. Several pharmacological treatments have been prescribed to the patient since OCD onset, following multiple consecutive hospitalizations in psychiatric departments: clomipramine 225 mg/day, fluoxetine 80 mg/day for more than 3 years, and paroxetine 60 mg/day. However, these treatments, as well as CBT, have had a very moderate effect on her symptoms. This case report of severe OCD associated with a bleach addiction-like syndrome is original in its dependence to the ‘‘substance’’ itself and not only to the washing behavior. As seen in some patients with severe, treatment-resistant disease, a stepwise natural history of the disease can be identified, with a progression towards an addiction to compulsion: the patient initially used bleach